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Tuesday, November 12, 2013

Half dose of MRI contrast feasible for rheumatoid arthritis

A half dose of the MRI contrast agent gadobenate dimeglumine provides just as much relevant diagnostic information as a full dose in 3-tesla imaging of patients with early rheumatoid arthritis, according to a study published in the July issue of Radiology.

The researchers did find, however, that the full dose of gadobenate dimeglumine had significantly better signal-to-noise and contrast-to-noise ratios than the half dose. The mean signal-to-noise ratio was 42.91 for the half dose, compared with 54.22 for the full dose, while the mean contrast-to-noise ratio was 12.81 for the half dose, compared with 24.78 for the full dose.
T1-weighted, fat-saturated, postcontrast 3-tesla MRI shows a half dose (a) and a full dose (b) of gadobenate dimeglumine in a 47-year-old man with early rheumatoid arthritis. The tendon sheath of the flexor tendons illustrates increased synovial enhancement, with tenosynovitis of the second flexor tendon scored as grade 3 (arrows) at both half dose and full dose. Images courtesy of Radiology.
Despite the disparity in contrast-to-noise and signal-to-noise ratios between the dosages, the diagnostic quality of the images was not affected, according to the authors. No region of synovial inflammation seen on full-dose contrast-enhanced MRI was missed at half dose.




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